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pentobarbital will lessen the extent or outcome of ketoconazole by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Significance Unfamiliar.pentobarbital will decrease the level or result of estropipate by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.pentobarbital will lower the level or outcome of fentan